FAILURE OF INITIAL TKI IN TREATING CML
Hello,
What symptoms will one experience if their TKI(s) begin to or have failed? Will they be the same as before diagnosis?
I've had to change treatment 4x so far since diagnosed in 2011. Each time as the treatment was failing I saw an increase in thumb-print-like bruising, hot flashes and cold chills, aches and pains (like having the flu, but no fever).
I have BCR-Abl bloodwork done every three months along with a CBC blood test for comparison. For me, eventually these increased symptoms were matched in the BCR-Abl bloodwork results.
On the flip side, when the treatment was becoming too harsh, I experienced intense rashes, increased fatigue, increased diarrhea and vomiting, swelling, and runny nose/cough (like having a cold). For me, eventually these increased symptoms were matched in the CBC bloodwork results.
It's like a balance that needs to be kept and when it goes wonky I have to find something that works better.
